CURASEPT’s modern dental approach and the implication of remineralisation

March 11, 2019

COLOGNE, Germany: A recent review on the remineralisation of tooth enamel published in the Journal of Dental Research stated that the goal of modern dentistry is to manage non-cavitated caries lesions non-invasively through remineralisation in an attempt to prevent disease progression and improve aesthetics, strength and function. It was in the 1970s when Jens Andreasen began to study the biological processes that govern the reparative phases that follow a trauma. He explained how even fractured teeth have a good chance of repair that will last for a long time.

Both primary and permanent teeth consist mainly of two highly mineralised tissues: the enamel and the dentine. The basic constituent of dentine, enamel and cementum is an inorganic salt arranged in hexagonal crystals that is called hydroxyapatite. From the first stage of eruption, the enamel and dental tissue are attacked daily by agents such as bacterial plaque, food, acidic substances, chewing and inappropriate oral hygiene practices. The single or combined action of these aggressive factors, if sufficiently prolonged, may lead to a loss of mineral substances from the surface of the tooth, with consequent weakening of dental structure and reduced masticatory capacity. Natural hydroxyapatite without added minerals does not have any particular capacity to remineralise.

Remineralisation in the oral environment is a natural process, which is, however, limited owing to many circumstances. Nowadays, there are many products on the market that use the term 'remineralisation'. Remineralisation means that the constituent minerals of the teeth, mainly calcium and phosphate ions, can be sourced to promote ion deposition into the crystal voids of the demineralised enamel. However, the substances that can claim to have this biomimetic property must be able to interact significantly with the tooth surfaces, even if conveyed in a simple toothpaste or mouthwash.

CURASEPT BIOSMALTO toothpastes and mouthwashes—for children and adults—contain a mixture of two different hydroxyapatites that allow the biomimetic properties necessary for effective remineralisation to develop: a hydroxyapatite substituted with magnesium, strontium and carbonate conjugated with chitosan called Bio-active Complex, and a fluoro-hydroxyapatite. Natural hydroxyapatite is a very stable mineral and, even if it comes in contact with damaged tooth areas, it is not able to release active ions. Products that contain only this type of hydroxyapatite are not very effective at remineralising, although they can still claim desensitising properties. The substitution with magnesium, strontium and carbonate, however, makes CURASEPT BIOSMALTO hydroxyapatite very reactive, able to quickly release bioactive elements that lead to true remineralisation, exploiting the normal biological processes. In addition, the presence of fluoride helps to create a mineralised surface that is more resistant to acid attacks and to better protect the tooth from erosion, abrasion and brushing damage. The formulation has been further enriched with strontium salts to reduce pain rapidly in cases of dentinal sensitivity.

In subjects particularly predisposed to strong demineralisation, for example, those suffering from Sjögren’s syndrome, diabetes or dry mouth, or undergoing chemotherapy or radiotherapy, wearers of orthodontic appliances and patients with white spots or with frequent caries, the additional use of CURASEPT BIOSMALTO Mousse is recommended. It is based on amorphous calcium phosphate enriched with carbonate and fluoride and externally citrate-functionalised. In contact with saliva, the complex dissolves immediately, rapidly releasing the active substances. In this way, a large amount of calcium, phosphate and fluoride is released directly on to the dental surface and in proximity to the demineralised lesions, while citrate facilitates the penetration of the ions into the tooth. The result is a rapid and intense remineralising action. CURASEPT BIOSMALTO Mousse is also recommended for children. To guarantee a correct remineralisation process, CURASEPT BIOSMALTO Mousse should be combined with products from the CURASEPT BIOSMALTO toothpaste line, selected according to the patient’s age.

For more information on CURASEPT, visit the company at IDS 2019 (Hall 5.2, Booth A031).

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